For Adults with Moderate to Severe Plaque Psoriasis

Psoriasis
and Inflammation

How are inflammation and psoriasis connected?

With plaque psoriasis, your body’s immune system becomes too active and causes inflammation. If not treated, the inflammation can cause plaques to develop and stay on the skin.

Too much inflammation can cause your body to produce too many skin cells. It takes most people over a month to produce new skin cells and shed old ones. With psoriasis, it takes about 4-5 days. Your body can’t get rid of these extra skin cells, so they start piling up on one another. This is what creates the plaques you see on your skin.

The skin regeneration process

NORMAL SKIN
Cells regenerate over a month

PLAQUE PSORIASIS
Cells regenerate every 4-5 days

A deeper understanding

Plaque psoriasis starts inside your body. Plaques may form on the skin when your body makes too much of a protein called interleukin-23 (IL-23)—causing an imbalanced immune system. That’s why plaque psoriasis is classified as an autoimmune disease.

AToo many proteins will cause the immune system to be imbalanced

BHaving too many proteins can cause ongoing inflammation

CThe skin cells grow and multiply too quickly

DExtra skin cells pile up to form plaques

USE

SKYRIZI is a prescription medicine used to treat adults with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy).

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about SKYRIZI^® (risankizumab-rzaa)?

SKYRIZI is a prescription medicine that may cause serious side effects, including:

Serious allergic reactions:

Stop using SKYRIZI and get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction:
- - fainting, dizziness, feeling lightheaded
  (low blood pressure)
- - swelling of your face, eyelids, lips, mouth,
  tongue, or throat
- - trouble breathing or throat tightness
- - chest tightness
- - skin rash, hives
- - itching

Infections:

SKYRIZI may lower the ability of your immune system to fight infections and may increase your risk of infections. Your healthcare provider should check you for infections and tuberculosis (TB) before starting treatment with SKYRIZI and may treat you for TB before you begin treatment with SKYRIZI if you have a history of TB or have active TB. Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with SKYRIZI.

Tell your healthcare provider right away if you have an infection or have symptoms of an infection, including:
- - fever, sweats, or chills
- - cough
- - shortness of breath
- - blood in your mucus (phlegm)
- - muscle aches
- - warm, red, or painful skin
  or sores on your body different from your psoriasis
- - weight loss
- - diarrhea or stomach pain
- - burning when you urinate or urinating more often than normal

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the ingredients in SKYRIZI. See the Medication Guide or Consumer Brief Summary for a complete list of ingredients.

Before using SKYRIZI, tell your healthcare provider about all of your medical conditions, including if you:

have any of the conditions or symptoms listed in the section "What is the most important information I should know about SKYRIZI?"
have an infection that does not go away or that keeps coming back.
have TB or have been in close contact with someone with TB.
have recently received or are scheduled to receive an immunization (vaccine). Medicines that interact with the immune system may increase your risk of getting an infection after receiving live vaccines. You should avoid receiving live vaccines right before, during, or right after treatment with SKYRIZI. Tell your healthcare provider that you are taking SKYRIZI before receiving a vaccine.
are pregnant or plan to become pregnant. It is not known if SKYRIZI can harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known if SKYRIZI passes into your breast milk.
become pregnant while taking SKYRIZI. You are encouraged to enroll in the Pregnancy Registry, which is used to collect information about the health of you and your baby. Talk to your healthcare provider or call 1-877-302-2161 to enroll in this registry.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of SKYRIZI?

SKYRIZI may cause serious side effects. See "What is the most important information I should know about SKYRIZI?"

Liver problems may happen while being treated for Crohn's disease or ulcerative colitis: A person with Crohn's disease who received SKYRIZI through a vein in the arm developed changes in liver blood tests with a rash that led to hospitalization. Your healthcare provider will do blood tests to check your liver before, during, and at least up to 12 weeks of treatment, and may stop treatment with SKYRIZI if you develop liver problems. Tell your healthcare provider right away if you notice any of the following symptoms: unexplained rash, nausea, vomiting, stomach (abdominal) pain, tiredness (fatigue), loss of appetite, yellowing of the skin and eyes (jaundice), and dark urine.

The most common side effects of SKYRIZI in people treated for Crohn’s disease and ulcerative colitis include: upper respiratory infections, headache, joint pain, stomach (abdominal) pain, injection site reactions, low red blood cells (anemia), fever, back pain, urinary tract infection, and rash.

The most common side effects of SKYRIZI in people treated for plaque psoriasis and psoriatic arthritis include: upper respiratory infections, headache, feeling tired, injection site reactions, and fungal skin infections.

These are not all the possible side effects of SKYRIZI. Call your doctor for medical advice about side effects.

Use SKYRIZI exactly as your healthcare provider tells you to use it.

SKYRIZI (risankizumab-rzaa) is available in a 150 mg/mL prefilled syringe and pen, a 600 mg/10 mL vial for intravenous infusion, and a 180 mg/1.2 mL or 360 mg/2.4 mL single-dose prefilled cartridge with on-body injector.

USES

SKYRIZI is a prescription medicine used to treat adults with:

moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy).
active psoriatic arthritis.
moderate to severe Crohn's disease.
moderate to severe ulcerative colitis.

US-SKZ-240065

Please see the Full Prescribing Information, including the Medication Guide, for SKYRIZI.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help.
Visit AbbVie.com/PatientAccessSupport to learn more.

Legal Notices. © 2024 AbbVie. All rights reserved. If you have any questions about AbbVie’s SKYRIZI.com website that have not been answered, click here. This website and the information contained herein is intended for use by US residents only, is provided for informational purposes only and is not intended to replace a discussion with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider and consider the unique characteristics of each patient.

USE

IMPORTANT SAFETY INFORMATION

SKYRIZI is a prescription medicine that may cause serious side effects, including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction:

• fainting, dizziness, feeling lightheaded (low blood pressure) • swelling of face, eyelids, lips, mouth, tongue, or throat • trouble breathing or throat tightness • chest tightness • skin rash, hives • itching

Infections: SKYRIZI may lower the ability of your immune system to fight infections and may increase

IMPORTANT SAFETY INFORMATION & USE

SKYRIZI is a prescription medicine that may cause serious side effects, including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help right away if you develop a serious allergic reaction.

Infections: SKYRIZI may lower your ability to fight infections and may increase risk of infections. Your healthcare provider should check you for infections and tuberculosis (TB)

USE

IMPORTANT SAFETY INFORMATION

SKYRIZI is a prescription medicine that may cause serious side effects, including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction:

Infections: SKYRIZI may lower the ability of your immune system to fight infections and may increase

IMPORTANT SAFETY INFORMATION & USE

SKYRIZI is a prescription medicine that may cause serious side effects, including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help right away if you develop a serious allergic reaction.

Infections: SKYRIZI may lower your ability to fight infections and may increase risk of infections. Your healthcare provider should check you for infections and tuberculosis (TB)

USE

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about SKYRIZI^® (risankizumab-rzaa)?

SKYRIZI is a prescription medicine that may cause serious side effects, including:

Serious allergic reactions:

Stop using SKYRIZI and get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction:
- - fainting, dizziness, feeling lightheaded
  (low blood pressure)
- - swelling of your face, eyelids, lips, mouth,
  tongue, or throat
- - trouble breathing or throat tightness
- - chest tightness
- - skin rash, hives
- - itching

Infections:

Tell your healthcare provider right away if you have an infection or have symptoms of an infection, including:
- - fever, sweats, or chills
- - cough
- - shortness of breath
- - blood in your mucus (phlegm)
- - muscle aches
- - warm, red, or painful skin
  or sores on your body different from your psoriasis
- - weight loss
- - diarrhea or stomach pain
- - burning when you urinate or urinating more often than normal

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the ingredients in SKYRIZI. See the Medication Guide or Consumer Brief Summary for a complete list of ingredients.

Before using SKYRIZI, tell your healthcare provider about all of your medical conditions, including if you:

have any of the conditions or symptoms listed in the section "What is the most important information I should know about SKYRIZI?"
have an infection that does not go away or that keeps coming back.
have TB or have been in close contact with someone with TB.
have recently received or are scheduled to receive an immunization (vaccine). Medicines that interact with the immune system may increase your risk of getting an infection after receiving live vaccines. You should avoid receiving live vaccines right before, during, or right after treatment with SKYRIZI. Tell your healthcare provider that you are taking SKYRIZI before receiving a vaccine.
are pregnant or plan to become pregnant. It is not known if SKYRIZI can harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known if SKYRIZI passes into your breast milk.
become pregnant while taking SKYRIZI. You are encouraged to enroll in the Pregnancy Registry, which is used to collect information about the health of you and your baby. Talk to your healthcare provider or call 1-877-302-2161 to enroll in this registry.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of SKYRIZI?

SKYRIZI may cause serious side effects. See "What is the most important information I should know about SKYRIZI?"

These are not all the possible side effects of SKYRIZI. Call your doctor for medical advice about side effects.

Use SKYRIZI exactly as your healthcare provider tells you to use it.

USES

SKYRIZI is a prescription medicine used to treat adults with:

moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy).
active psoriatic arthritis.
moderate to severe Crohn's disease.
moderate to severe ulcerative colitis.

US-SKZ-240065

Psoriasis and Inflammation

How are inflammation and psoriasis connected?

The skin regeneration process

A deeper understanding

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USE

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about SKYRIZI® (risankizumab-rzaa)?

SKYRIZI is a prescription medicine that may cause serious side effects, including:

Serious allergic reactions:

Infections:

Before using SKYRIZI, tell your healthcare provider about all of your medical conditions, including if you:

What are the possible side effects of SKYRIZI?

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IMPORTANT SAFETY INFORMATION

What is the most important information I should know about SKYRIZI® (risankizumab-rzaa)?

SKYRIZI is a prescription medicine that may cause serious side effects, including:

Serious allergic reactions:

Infections:

Before using SKYRIZI, tell your healthcare provider about all of your medical conditions, including if you:

What are the possible side effects of SKYRIZI?

USES

Psoriasis
and Inflammation

What is the most important information I should know about SKYRIZI^® (risankizumab-rzaa)?

What is the most important information I should know about SKYRIZI^® (risankizumab-rzaa)?